PT  - JOURNAL ARTICLE
AU  - Borel, Anne-Laure
AU  - Pépin, Jean-Louis
AU  - Nasse, Laure
AU  - Baguet, Jean-Philippe
AU  - Netter, Sophie
AU  - Benhamou, Pierre-Yves
TI  - Short Sleep Duration Measured by Wrist Actimetry Is Associated With Deteriorated Glycemic Control in Type 1 Diabetes
AID  - 10.2337/dc12-2038
DP  - 2013 Oct 01
TA  - Diabetes Care
PG  - 2902--2908
VI  - 36
IP  - 10
4099  - http://care.diabetesjournals.org/content/36/10/2902.short
4100  - http://care.diabetesjournals.org/content/36/10/2902.full
SO  - Diabetes Care2013 Oct 01; 36
AB  - OBJECTIVE Sleep restriction has been associated with deteriorated insulin sensitivity. The effects of short sleep duration have been explored little in patients with type 1 diabetes. This study addresses the question of whether sleep curtailment affects HbA1c levels in patients with type 1 diabetes.RESEARCH DESIGN AND METHODS Seventy-nine adult patients with type 1 diabetes (median age 40 years [IQR 23–49]; 47% men) were recruited to wear a wrist actimetry sensor during 3 consecutive days to assess mean sleep duration during normal daily life. A subsample of 37 patients also performed 24-h ambulatory blood pressure monitoring (ABPM). Medical history, sleep questionnaires, and diabetes-related quality of life (DQOL) were assessed.RESULTS Patients having shorter sleep duration—less than 6.5 h (n = 21)—had higher levels of HbA1c (P = 0.01) than patients with longer sleep duration, above 6.5 h (n = 58). In a multivariable regression model including shorter versus longer sleep duration, diabetes duration, DQOL score, and daily activity, sleep duration was the only variable independently associated with HbA1c (R2 = 10%). In patients who performed 24-h ABPM, patients with a nondipping pattern of blood pressure exhibited shorter sleep duration than patients with a dipping pattern of blood pressure.CONCLUSIONS Shorter sleep duration is associated with higher HbA1c levels in patients with type 1 diabetes, as well as with a nondipping pattern of blood pressure, anticipating a long-term deleterious impact on the risk of microvascular complications. Further studies should test whether extending the duration of sleep may improve both HbA1c and blood pressure in type 1 diabetes.