RT Journal Article
SR Electronic
T1 Diabetes Is an Independent Predictor for Severe Osteoarthritis
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP DC_120924
DO 10.2337/dc12-0924
A1 Schett, Georg
A1 Kleyer, Arndt
A1 Perricone, Carlo
A1 Sahinbegovic, Enijad
A1 Iagnocco, Annamaria
A1 Zwerina, Jochen
A1 Lorenzini, Rolando
A1 Aschenbrenner, Franz
A1 Berenbaum, Francis
A1 D’Agostino, Maria-Antonietta
A1 Willeit, Johann
A1 Kiechl, Stefan
YR 2012
UL http://care.diabetesjournals.org/content/early/2012/10/02/dc12-0924.abstract
AB OBJECTIVE To evaluate if type 2 diabetes is an independent risk predictor for severe osteoarthritis (OA).RESEARCH DESIGN AND METHODS Population-based cohort study with an age- and sex-stratified random sample of 927 men and women aged 40–80 years and followed over 20 years (1990–2010).RESULTS Rates of arthroplasty (95% CI) were 17.7 (9.4–30.2) per 1,000 person-years in patients with type 2 diabetes and 5.3 (4.1–6.6) per 1,000 person-years in those without (P < 0.001). Type 2 diabetes emerged as an independent risk predictor for arthroplasty: hazard ratios (95% CI), 3.8 (2.1–6.8) (P < 0.001) in an unadjusted analysis and 2.1 (1.1–3.8) (P = 0.023) after adjustment for age, BMI, and other risk factors for OA. The probability of arthroplasty increased with disease duration of type 2 diabetes and applied to men and women, as well as subgroups according to age and BMI. Our findings were corroborated in cross-sectional evaluation by more severe clinical symptoms of OA and structural joint changes in subjects with type 2 diabetes compared with those without type 2 diabetes.CONCLUSIONS Type 2 diabetes predicts the development of severe OA independent of age and BMI. Our findings strengthen the concept of a strong metabolic component in the pathogenesis of OA.