RT Journal Article
SR Electronic
T1 International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 1147
OP 1154
DO 10.2337/dc18-2316
VO 42
IS 6
A1 Danne, Thomas
A1 Garg, Satish
A1 Peters, Anne L.
A1 Buse, John B.
A1 Mathieu, Chantal
A1 Pettus, Jeremy H.
A1 Alexander, Charles M.
A1 Battelino, Tadej
A1 Ampudia-Blasco, F. Javier
A1 Bode, Bruce W.
A1 Cariou, Bertrand
A1 Close, Kelly L.
A1 Dandona, Paresh
A1 Dutta, Sanjoy
A1 Ferrannini, Ele
A1 Fourlanos, Spiros
A1 Grunberger, George
A1 Heller, Simon R.
A1 Henry, Robert R.
A1 Kurian, Martin J.
A1 Kushner, Jake A.
A1 Oron, Tal
A1 Parkin, Christopher G.
A1 Pieber, Thomas R.
A1 Rodbard, Helena W.
A1 Schatz, Desmond
A1 Skyler, Jay S.
A1 Tamborlane, William V.
A1 Yokote, Koutaro
A1 Phillip, Moshe
YR 2019
UL http://care.diabetesjournals.org/content/42/6/1147.abstract
AB Sodium–glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.