RT Journal Article
SR Electronic
T1 Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 1941
OP 1944
DO 10.2337/dc20-0171
VO 43
IS 8
A1 Šuput Omladič, Jasna
A1 Slana Ozimič, Anka
A1 Vovk, Andrej
A1 Šuput, Dušan
A1 Repovš, Grega
A1 Dovc, Klemen
A1 Bratina, Nataša
A1 Avbelj Stefanija, Magdalena
A1 Battelino, Tadej
YR 2020
UL http://care.diabetesjournals.org/content/43/8/1941.abstract
AB OBJECTIVE To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).RESULTS Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed.CONCLUSIONS Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.