PT  - JOURNAL ARTICLE
AU  - Karasik, Avraham
AU  - O'Hara, Carl
AU  - Srikanta, S
AU  - Swift, Michael
AU  - Soeldner, J Stuart
AU  - Kahn, C Ronald
AU  - Herskowitz, Raymonde D
TI  - Genetically Programmed Selective Islet β-Cell Loss in Diabetic Subjects With Wolfram's Syndrome
AID  - 10.2337/diacare.12.2.135
DP  - 1989 Feb 01
TA  - Diabetes Care
PG  - 135--138
VI  - 12
IP  - 2
4099  - http://care.diabetesjournals.org/content/12/2/135.short
4100  - http://care.diabetesjournals.org/content/12/2/135.full
SO  - Diabetes Care1989 Feb 01; 12
AB  - Insulin-producing (5-cells were selectively absent from the islets of Langerhans in postmortem specimens from two patients with Wolfram's syndrome. In families with multiple cases of this syndrome, we found a very high concordance rate (r = .910, P < .001) among siblings for age at onset of diabetes mellitus. Taken together with the lack of markers for an autoimmune process, these findings suggest that diabetes mellitus in this syndrome results from genetically programmed selective p-cell death.