RT Journal Article
SR Electronic
T1 Improved Insulin Response and Action by Chronic Magnesium Administration in Aged NIDDM Subjects
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 265
OP 269
DO 10.2337/diacare.12.4.265
VO 12
IS 4
A1 Paolisso, Giuseppe
A1 Sgambato, Saverio
A1 Pizza, Gennaro
A1 Passariello, Nicola
A1 Varricchio, Michele
A1 D'Onofrio, Felice
YR 1989
UL http://care.diabetesjournals.org/content/12/4/265.abstract
AB In eight aged non-insulin-dependent diabetes mellitus (NIDDM) subjects, insulin response and action were studied before and after chronic magnesium supplementation (2 g/day) to diet. Chronic magnesium supplementation to diet versus placebo produced 7) a significant increase in plasma (0.83 ± 0.05 vs. 0.78 ± 0.06 mM, P < .05) and erythrocyte (2.03 ± 0.06 vs. 1.88 ± 0.09 mM, P < .01) magnesium levels, 2) an increase in acute insulin response (AIR) (4.0 ± 0.6 vs. - 1 .6 ± 0.6 mU/L, P < .05) to glucose pulse, and 3) an increase in glucose infusion rate (GIR) (3.6 ± 0.6 vs. 2.9 ± 0.5 mg kg∼1 min−1 P < .025) calculated in the last 60 min of a euglycemic-hyperinsulinemic (100U m2 · min−1 during 180 min) glucose clamp. Net increase in AIR, glucose disappearance rate after glucose pulse, and GIR were significantly and positively correlated to the net increase in erythrocyte magnesium content calculated after chronic magnesium supplementation to diet. In conclusion, our data suggest that NIDDM subjects may benefit from therapeutic chronic administration of magnesium salts.