RT Journal Article SR Electronic T1 Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities JF Diabetes Care JO Diabetes Care FD American Diabetes Association SP 898 OP 900 DO 10.2337/diacare.13.8.898 VO 13 IS 8 A1 Guillausseau, Pierre Jean A1 Charles, Marie-Aline A1 Paolaggi, Françoise A1 Timsit, José A1 Chanson, Philippe A1 Peynet, Jacqueline A1 Godard, Valérie A1 Eschwege, Eveline A1 Rousselet, François A1 Lubetzki, Jean YR 1990 UL http://care.diabetesjournals.org/content/13/8/898.abstract AB Total glycosylated hemoglobin (HbA1) and fructosamine were evaluated as screening tools for detection of glucose-tolerance abnormalities in 144 asymptomatic subjects undergoing a 75-g oral glucose tolerance test. Subjects were classified according to World Health Organization criteria as having normal (n = 78), impaired (n = 40), or diabetic (n = 26) glucose tolerance. We found good specificity for HbA1 and fructosamine (100 and 97%, respectively) but low sensitivity (15 and 19%, respectively). At the intersection of the curves of sensitivity and specificity drawn from various thresholds of normality, both sensitivity and specificity were 75% for HbA1 and 55% for fructosamine. Thus, neither HbA1 nor fructosamine seems to be suitable for the diagnosis of mild abnormalities in glucose tolerance.