PT  - JOURNAL ARTICLE
AU  - Kobayashi, Masashi
AU  - Shigeta, Yukio
AU  - Hirata, Yukimasa
AU  - Omori, Yasue
AU  - Sakamoto, Nobuo
AU  - Nambu, Seiki
AU  - Baba, Shigeaki
TI  - Improvement of Glucose Tolerance in NIDDM by Clofibrate Randomized Double-Blind Study
AID  - 10.2337/diacare.11.6.495
DP  - 1988 Jun 01
TA  - Diabetes Care
PG  - 495--499
VI  - 11
IP  - 6
4099  - http://care.diabetesjournals.org/content/11/6/495.short
4100  - http://care.diabetesjournals.org/content/11/6/495.full
SO  - Diabetes Care1988 Jun 01; 11
AB  - A randomized double-blind study was performed to examine the effect of clofibrate on glucose tolerance in subjects with non-insulin-dependent diabetes mellitus (NIDDM). Clofibrate (1.5 g/day) or placebo was administered to 70 patients and an oral glucose tolerance test (OGTT) was performed before and 12 wk after treatment. Blood glucose levels were significantly improved in clofibrate-treated groups at all time points during OGTT, whereas there was no change in insulin levels. Improvement of fasting glucose levels required 8 wk of clofibrate treatment. Insulin binding to erythrocytes demonstrated no significant change in the clofibrate-treated subjects.A randomized double-blind study was performed to examine the effect of clofibrate on glucose tolerance in subjects with non-insulin-dependent diabetes mellitus (NIDDM). Clofibrate (1.5 g/day) or placebo was administered to 70 patients and an oral glucose tolerance test (OGTT) was performed before and 12 wk after treatment. Blood glucose levels were significantly improved in clofibrate-treated groups at all time points during OGTT, whereas there was no change in insulin levels. Improvement of fasting glucose levels required 8 wk of clofibrate treatment. Insulin binding to erythrocytes demonstrated no significant change in the clofibrate-treated subjects. These results suggest that clofibrate improves glucose tolerance in NIDDM subjects without a change in insulin receptors and that clofibrate increases insulin sensitivity through an unknown postreceptor mechanism.