Table 2

Insulin delivery and daytime and nighttime glucose control during the home phase

Closed loopSAPP*
Insulin delivery
 Total basal (units/day)20.1 (17.2–24.7)18.9 (15.4–20.4)0.017
 Total bolus (units/day)18.9 (15.5–25.5)26.5 (20.6–30.1)0.002
 Total daily dose (units)39.1 (34.7–45.7)44.7 (36.3–51.0)0.109
 SD of basal insulin0.7 (0.6–0.9)0.2 (0.1–0.2)<0.001
Daytime and nighttime glucose control
 Daytime (0700–2259 h)
  Mean glucose8.1 ± 1.08.5 ± 1.20.147
  Percent time in target (3.9–10.0 mmol/L)72.5 (63.4–78.6)65.4 (54.6–71.0)0.017
  AUCday <3.5 mmol/L (mmol/L × min)2.3 (0.9–19.3)6.3 (0.4–30.1)0.225
 Nighttime (2300–0659 h)
  Mean glucose8.3 ± 1.39.3 ± 1.10.015
  Percent time in target (3.9–8.0 mmol/L)48.4 (32.5–64.5)35.1 (28.4–47.5)0.013
  AUCday <3.5 mmol/L (mmol/L × min)3.1 (0–17.5)3.2 (0.1–33.5)0.163
  • Data are means ± SD or median (IQR). AUC calculated per day.

  • *Paired samples t tests or Wilcoxon signed rank test.

  • †Adjusted for CGM measurement error assuming a relative absolute deviation of 15%.