Table 3

Hemostatic and fibrinolytic variables in patients with type 1 diabetes and control subjects

Type 1 diabetic subjects (n = 236)Control subjects
(n = 78)P#P*
Fibrinogen (g/L)2.98 ± 0.803.19 ± 0.600.04<0.0001
Fragment 1+2 (pmol/L)220 (164–294)235 (178–332)0.0470.35
PAI-1 activity (U/mL)2.19 (0.96–5.42)4.25 (1.95–9.00)<0.00010.0012
tPA activity (U/mL)0.86 (0.61–1.07)M.D.
tPA/PAI-1 complex (µg/L)2.25 (1.7–3.0)2.6 (1.8–3.4)0.240.98
Antiplasmin, plasma (mg/L)78.5 ± 13.383.2 ± 15.40.0380.032
Antiplasmin, fibrin (mg/L)1.65 ± 0.251.35 ± 0.18<0.000001<0.000001
PAP complex (mg/L)0.25 (0.21–0.32)0.24 (0.20–0.30)0.360.33
FXIII (AU/mL)0.83 ± 0.190.88 ± 0.200.0770.30
d-dimer (µg/L)35.8 (22.8–58.2)36.5 (19–62.3)0.510.64
Clot lysis time (s)858 ± 228927 ± 2080.0140.0090
  • Data are means ± SD or median (lower to upper quartiles). M.D., missing data.

  • #Univariate analysis.

  • *P values adjusted for age, use of statins, and systolic and diastolic blood pressure by ANCOVA.