Table 2

Characteristics (median [quartile 1, quartile 3]) or n (%) of the people and their treatment after 12 months of insulin treatment, according to their weight gain at 12 months, and β coefficients from linear models adjusted for the investigational site as a random factor

Weight gain at 12 months (kg)β coefficient*(95% CI)P
Item<2.0 n = 1,0872.0–4.9 n = 5815.0–9.9 n = 405≥10 n = 106
A1C (%)7.3 (6.7, 8.3)7.6 (6.9, 8.4)7.6 (6.9, 8.5)7.7 (6.8, 8.6)1.968*(0.794 to 3.141)0.001
A1C (mmol/mol)56 (50, 67)60 (52, 68)60 (52, 69)61 (51, 70)0.180(0.073 to 0.287)0.001
Insulin regimen<0.001
 Basal insulin alone531 (49%)256 (44%)104 (26%)30 (28%)Reference
 Basal + mealtime192 (18%)129 (22%)119 (29%)37 (35%)1.964(1.441 to 2.487)<0.001
 Mealtime alone39 (4%)16 (2%)10 (2%)1 (1%)−0.268(–1.443 to 0.908)0.665
 Premix276 (25%)146 (25%)137 (34%)32 (30%)1.269(0.770 to 1.767)<0.001
 Other49 (4%)34 (6%)35 (9%)6 (6%)1.686(0.796 to 2.576)<0.001
Other diabetes drugs0.008
 None360 (33%)215 (37%)175 (43%)49 (46%)Reference
 One410 (38%)182 (31%)147 (36%)37 (35%)−0.522(–0.987 to 60.058)0.027
 Two267 (25%)155 (27%)70 (17%)17 (16%)−0.878(–1.415 to –0.342)0.001
 Three or more50 (5%)29 (5%)13 (3%)3 (3%)−0.948(–1.949 to 0.053)0.063
Biguanides532 (49%)267 (46%)167 (41%)46 (43%)−0.504(–0.907 to –0.101)0.014
Sulfonylureas365 (34%)201 (35%)87 (22%)23 (22%)−0.584(–1.026 to –0.142)0.010
Daily insulin dose (IU/kg)0.33 (0.21, 0.52)0.40 (0.26, 0.56)0.46 (0.33, 0.63)0.51 (0.33, 0.64)1.529(1.202 to 1.856)<0.001
  • *For categorical measures, β coefficients are given for yes vs. no, or against the reference group stated.

  • †Data were loge transformed for analysis, so the β coefficients are for loge of a unit difference.