Table 1

Glucose control during closed loop and SAP over the 7-day home phase and 1-day stay at the clinical research facility in 17 patients with type 1 diabetes

Closed loopSAPP*
Free-living conditions (7 days); based on CGM
 Mean glucose (mmol/L)**8.1 ± 1.08.8 ± 1.00.027
 SD of glucose (mmol/L)**2.9 ± 0.63.3 ± 0.80.034
 CV of glucose (%)**35.7 ± 5.937.7 ± 7.60.149
 Percent time spent at glucose level
  3.9–10.0 mmol/L74.5 (61.1–78.9)61.8 (53.3–70.1)0.005
  3.9–10.0 mmol/L**75.3 (62.1–82.0)62.6 (54.8–72.4)0.006
  3.9–8.0 mmol/L54.9 (42.2–58.3)43.3 (33.0–49.1)0.017
  >10.0 mmol/L21.9 (16.7–32.3)30.5 (24.3–41.4)0.013
  >16.7 mmol/L1.5 (0.5–3.5)3.3 (1.4–5.0)0.049
  <3.9 mmol/L3.7 (2.2–7.9)5.0 (2.3–8.5)0.339
  <2.8 mmol/L0.3 (0.2–1.1)0.6 (0.2–1.6)0.124
 AUCday <3.5 mmol/L (mmol/L × min)**2.9 (1.4–15.8)7.9 (1.3–24.1)0.149
  LBGI**0.6 (0.5–1.4)0.9 (0.5–1.5)0.309
  HBGI**4.5 (3.3–7.2)7.2(4.8–9.1)0.039
Clinical research facility (1 day), based on YSI glucose
 Mean glucose (mmol/L)8.2 ± 1.08.6 ± 1.60.292
 SD of glucose (mmol/L)2.4 ± 0.72.8 ± 0.70.079
 CV of glucose (%)27.5 ± 8.333.0 ± 8.40.095
 Percent time spent at glucose level
  3.9–10.0 mmol/L73.7 (63.4–84.1)60.7 (49.2–76.8)0.044
  <3.9 mmol/L1.8 (0–5.8)4.7 (0–7.8)0.221
  >10.0 mmol/L21.4 (13.6–33.5)24.5 (16.0–49.1)0.124
  • Data are means ± SD or median (IQR). AUC calculated per day. HBGI, high blood glucose index; LBGI, low blood glucose index.

  • *Paired samples t test or Wilcoxon signed rank test.

  • **Based on native CGM.

  • †Adjusted for CGM measurement error assuming a relative absolute deviation of 15%.