Table 7 —

Combined haplotype analysis for ABCC8

GenotypenExon 16 −3 C/TExon 18 Thr759ThrSI*AIRglucoseSI*AIRtolbutamide
135C/CC/C0.096 (0.061–0.152)0.023 (0.019–0.028)
212C/CC/T0.098 (0.044–0.220)0.029 (0.020–0.040)
345C/TC/C0.057 (0.034–0.097)0.019 (0.015–0.024)
47C/TC/T0.056 (0.021–0.145)0.012 (0.008–0.018)
520T/TC/C0.134 (0.065–0.277)0.027 (0.020–0.036)
  • Estimated means (95% CIs) are given from the mixed effects model, adjusted for covariates, and transformed back to linear scale. In pairwise comparisons, SI*AIRglucose (DI) was significantly different for genotype 3 vs. genotype 5; SI*AIRtolbutamide (DIT) was significantly different for genotypes 1 vs. 4, 2 vs. 3, 2 vs. 4, 3 vs. 4, 3 vs. 5, and 4 vs. 5 (all <0.05).