Table 2 —

Comparison of clinical features of Chinese patients with familial type 2 diabetes according to age of diagnosis of diabetes and obesity status

CharacteristicsEarly-onset patients with unknown etiologyLate-onset patientsEarly-onset nonobese patientsEarly-onset obese patientsLate-onset nonobese patientsLate-onset obese patients
n119    290   54   65   156   134   
Sex (%)
 Men37 (31)98 (34)12 (22)25 (38)56 (36)42 (31)
 Women82 (69)192 (66)42 (78)40 (62)100 (64)92 (69)
Current age (year)34 ± 556 ± 934 ± 533 ± 556 ± 1055 ± 9
Age at diagnosis (year)30 ± 652 ± 831 ± 529 ± 652 ± 852 ± 8
Duration of disease (year)4.0 ± 3.94.0 ± 4.23.9 ± 3.84.2 ± 4.04.5 ± 4.43.5 ± 3.9
Family history
 Father46 (39)64 (22)21 (39)27 (42)28 (18)36 (27)
 Mother75 (63)119 (41)38 (70)39 (60)65 (42)54 (40)
 Sibling36 (30)154 (53)15 (28)20 (31)85 (54)69 (51)
BMI (kg/m2)26.2 ± 4.725.0 ± 3.722.3 ± 1.829.5 ± 3.822.4 ± 1.828.0 ± 3.1
Waist circumference (cm)
 Men90 ± 1187 ± 978 ± 695 ± 981 ± 694 ± 7
 Women81 ± 1183 ± 974 ± 589 ± 1078 ± 689 ± 8
Systolic BP (mmHg)117 ± 14136 ± 22114 ± 13120 ± 14134 ± 23139 ± 21
Diastolic BP (mmHg)75 ± 983 ± 1174 ± 977 ± 1080 ± 1186 ± 12
TG (mmol/l)1.4 (0.9–2.0)1.4 (1.0–2.0)1.0 (0.7–1.5)1.7 (1.0–2.4)1.4 (0.9–1.9)1.6 (1.1–2.1)
TC (mmol/l)5.3 ± 1.25.6 ± 1.35.1 ± 1.05.4 ± 1.45.6 ± 1.35.5 ± 1.2
HDL-C (mmol/l)1.2 ± 0.31.2 ± 0.31.3 ± 0.31.1 ± 0.31.3 ± 0.41.2 ± 0.3
TC/HDL-C4.7 ± 1.84.7 ± 1.54.0 ± 1.05.3 ± 2.24.7 ± 1.74.7 ± 1.3
LDL-C (mmol/l)3.3 ± 0.93.5 ± 1.03.2 ± 0.83.4 ± 1.03.5 ± 1.03.5 ± 1.0
Fasting glucose (mmol/l)8.2 ± 3.19.1 ± 3.67.6 ± 2.88.7 ± 3.39.6 ± 3.88.6 ± 3.3
HbA1c (%)7.5 ± 1.88.0 ± 1.97.1 ± 1.87.9 ± 1.88.2 ± 2.17.7 ± 1.5
Fasting insulin (pmol/l)*105 (72–164)87 (51–146)89 (60–149)120 (78–179)76 (43–129)99 (57–157)
HOMAIR index*34.7 (22.9–55.8)33.1 (19.2–62.8)27.5 (16.0–46.7)42.7 (27.6–58.2)29.9 (14.7–61.9)36.4 (19.7–64.2)
Urinary ACR (mg/mmol)2.6 (0.7–6.1)2.8 (0.8–7.1)1.2 (0.6–1.9)5.1 (0.9–24.1)2.6 (0.9–5.8)3.2 (0.8–8.4)
Treatment (%)
 Diet71 (60)93 (32)35 (65)36 (55)55 (35)38 (28)
 Oral drugs39 (33)176 (61)17 (31)22 (34)89 (57)87 (65)
 Insulin9 (8)21 (7)2 (4)7 (11)12 (8)9 (7)
Retinopathy (%)10 (8)62 (21)1 (2)9 (14)38 (24)24 (18)
Albuminuria (%)48 (40)110 (38)8 (15)40 (62)53 (34)57 (43)
Neuropathy (%)4 (3)29 (10)2 (4)2 (3)13 (8)16 (12)
  • Data are expressed as n, n (%), means ± SD, or the geometric mean (25th and 75th percentiles). Data are compared between early- and late-onset patients, between early-onset nonobese and obese patients, and between late-onset nonobese and obese patients.

  • *

    * Only measured in patients not treated with insulin.

  • P < 0.05;

  • P < 0.001.