Table 1

Effect of intervention on change in clinical and prescribed medication variables: ADDITION-Europe

Intervention effect**
Mean change from baseline to follow-up95% CI
RCITEstimate (OR)LowerUpper
Clinical variable
 Current smokers (%)−4.9−5.21.060.771.45
 BMI (kg/m2)−0.5−0.50.02−0.170.22
 Systolic blood pressure (mmHg)−11.9−13.5−2.86−4.51−1.20
 Diastolic blood pressure (mmHg)−6.2−6.7−1.44−2.30−0.58
 HbA1c (%)−0.3−0.4−0.08−0.14−0.02
 Total cholesterol (mmol/L)−1.2−1.4−0.27−0.34−0.19
 HDL cholesterol (mmol/L)0.10.10.00−0.030.02
 LDL cholesterol (mmol/L)−1.2−1.3−0.20−0.26−0.13
 Triglycerides (mmol/L)−0.1−0.10.960.930.99
 Creatinine (μmol/L)−3.7−2.21.810.103.53
 eGFR (mL/min)6.44.3−1.39−2.970.19
 ACR2.52.50.920.821.04
 Any albuminuria (%)0.00.00.810.651.03
Self-reported medication
 Any glucose-lowering drug (%)56.364.51.531.251.87
 Any antihypertensive drug (%)31.637.41.611.272.04
 Any cholesterol-lowering drug (%)58.464.01.521.231.90
 Aspirin (%)29.955.53.372.764.12
  • **Intervention effects represent the following: for continuous variables, except triglyceride levels and ACR, the difference in mean change comparing IT vs. RC; for triglyceride levels and ACR, the ratio of geometric mean changes comparing IT vs. RC; and for binary variables (i.e., current smokers, any albuminuria, all medications), the OR comparing IT vs. RC.