Table 1 —

Clinical profiles of type 2 diabetic subjects with various stages of nephropathy

ControlAll patients with diabetesStages of diabetic nephropathy
Stage 1Stage 2Stage 3Stage 4
n54 (28/26)75 (46/29)3917910
Age (years)53.8 ± 1.456.0 ± 1.154.6 ± 1.753.9 ± 2.257.0 ± 2.464.0 ± 1.3
BMI (kg/m2)22.0 ± 0.322.4 ± 0.322.2 ± 0.622.8 ± 0.722.4 ± 0.922.8 ± 0.6
Duration of diabetes (years)11.1 ± 1.08.9 ± 1.18.1 ± 1.315.9 ± 2.320.4 ± 4.2††
Smoking index (cigarette-years)183 ± 43417 ± 59*472 ± 88466 ± 112289 ± 192230 ± 117
Systolic blood pressure (mmHg)122 ± 3135 ± 3**120 ± 2137 ± 6159 ± 7†††165 ± 8†††
Diastolic blood pressure (mmHg)77 ± 273 ± 170 ± 176 ± 381 ± 376 ± 6
HbA1c (%)8.7 ± 0.39.2 ± 0.48.5 ± 0.48.6 ± 0.87.0 ± 0.4
Creatinine (μmol/l)72 ± 2113 ± 1759 ± 268 ± 490 ± 16416 ± 68†††
Log vitamin B12 (pmol/l)2.76 ± 0.022.78 ± 0.032.65 ± 0.042.79 ± 0.052.82 ± 0.08
Log folate (nmol/l)1.20 ± 0.021.20 ± 0.031.16 ± 0.031.22 ± 0.061.22 ± 0.05
tHcy (μmol/l)8.7 ± 0.312.0 ± 0.7***9.6 ± 0.411.2 ± 1.113.3 ± 1.821.6 ± 2.0
Log tHcy (μmol/l)0.920 ± 0.0161.040 ± 0.02***0.966 ± 0.0181.017 ± 0.0441.092 ± 0.060*1.319 ± 0.040***†††
  • Data are mean ±SE or n.

  • *

    * P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

  • **

    ** P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

  • ***

    *** P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

  • P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.

  • ††

    †† P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.

  • †††

    ††† P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.