Table 3 —

Standard correlation coefficients (β) on multiple regression analyses for clinical factors affecting log-transformed plasma total homocysteine levels in all 75 patients with diabetes and those of 59 patients with type 2 diabetes with creatinine clearance >60 ml/min

Independent variablesAll patients with diabetes
Patients with diabetes with creatinine clearance >60 ml/min
Model 1Model 2Model 3Model 4
Age0.1230.1010.2970.241
Gender0.1330.179*0.213*0.296*
Systolic blood pressure0.1510.0780.1220.003
HbA1c–0.008–0.0700.0140.165
Uric acid0.2980.3210.308*0.368
Log vitamin B12–0.331–0.329–0.386–0.375
Log folate–0.106–0.177*–0.187–0.336*
Creatinine clearance–0.521–0.529–0.217–0.252
Insulin sensitivity index–0.245–0.438
R20.7100.7500.4340.561
  • Models 1 and 2 were used for all 75 patients with diabetes, and models 3 and 4 were used for 59 patients with diabetes with creatinine clearance >60 ml/min. In all models, log-transformed plasma tHcy level (log tHcy) was entered as a dependent variable. For sex, female was entered as 0 and male was entered as 1. Creatinine clearance was estimated by Cockcroft-Gault derived equation. The serum levels of vitamin B12 and folate were log-transformed (log vitamin B12 and log folate). Standard correlation coefficients (β) and multiple coefficients of determination (R2) are shown with level of significance.

  • *

    * P < 0.05;

  • P < 0.01;

  • P < 0.0001.