Table 2 —

−23 Hph I insulin genotypes in monozygotic twins with type 1 diabetes

INS Genotypes
+/++/− (plus −/−)
Concordant twins (n = 40)0.875 (n = 35)0.125 (n = 5)
Discordant twins (n = 37)0.595 (n = 22)0.405 (n = 15)
British caucasoid, ICA-negative controls (n = 63)*0.54 (n = 34)0.46 (n = 29)
Type 1 diabetes (n = 116)*0.72 (n = 83)0.28 (n = 33)
  • Concordant twins versus discordant twins (P = 0.005); concordant twins versus controls (P = 0.0001); concordant twins versus type 1 diabetes (P = 0.054); discordant twins versus controls (P = 0.68); discordant twins versus type 1 diabetes (P = 0.22); type 1 diabetes versus controls (P = 0.022).

  • *

    * Results taken from ref. 31. Patients with type 1 diabetes were serially selected from the Barts Oxford study, which is a population-based study of type 1 diabetes in the Oxfordshire region. The controls were all ICA-negative and were aged-matched to the subjects with type 1 diabetes. The disease-associated allele is designated (+).