Table 3 —

Hph I high-risk insulin genotype and HLA DQB1*0201/*0302 combinations in monozygotic twins with type 1 diabetes

TwinsINS negative DQ negative*INS positive DQ positiveINS negative DQ positiveINS positive DQ negative
Concordant (n = 40)0.05 (n = 2)0.40 (n = 16)0.075 (n = 3)0.475 (n = 19)
Discordant (n = 37)0.324 (n = 12)0.189 (n = 7)0.081 (n = 3)0.405 (n = 15)
  • INS, possession of Hph I high-risk genotype (+/+); DQ, possession of HLA DQB1*0201 and/or *0302. Overall Pearson χ2, P = 0.012; likelihood exact χ2, P = 0.011.

  • *

    * 2 × 2 Pearson χ2, P = 0.002.