Table 3 —

Age-adjusted standardized hazards ratios for death by cancer according to fasting and 2-h insulin concentrations, adjusted additionally for BMI, tobacco smoking, erythrocyte MCV and chronic alcohol use, and for all factors (the aforementioned factors plus glucose concentration and systolic blood pressure): the Paris Prospective Study 23.8 years of follow-up

Cancer typeAge-adjusted ratioRatios adjusted for age and
BMITobacco smokingMCV, chronic alcohol useAll factors
Fasting insulin values
 All neoplasms0.96 (0.89–1.03)1.00 (0.93–1.08)0.99 (0.92–1.06)0.99 (0.92–1.06)1.02 (0.94–1.10)
 Lip, oral cavity, pharynx0.55 (0.41–0.75)0.66 (0.48–0.91)0.57 (0.42–0.77)0.57 (0.42–0.77)0.63 (0.44–0.88)
 Digestive organs, peritoneuim
  Esophagus0.74 (0.55–1.01)0.96 (0.68–1.34)0.77 (0.57–1.05)0.72 (0.53–0.99)0.88 (0.62–1.25)
  Stomach0.91 (0.62–1.32)0.95 (0.63–1.43)0.91 (0.62–1.32)0.93* (0.63–1.37)0.90* (0.59–1.37)
  Colon, rectum, anus1.22 (0.95–1.56)1.07 (0.82–1.39)1.21 (0.95–1.55)1.22* (0.95–1.58)1.05* (0.79–1.38)
  Liver2.72 (1.87–3.94)2.45 (1.63–3.70)2.71 (1.88–3.92)2.64 (1.77–3.92)2.18 (1.38–3.45)
  Pancreas1.18 (0.84–1.66)1.21 (0.83–1.75)1.21 (0.86–1.71)1.24 (0.95–2.33)1.24 (0.84–1.83)
 Respiratory, intrathoracic organs
  Larynx0.63 (0.47–0.83)0.77 (0.56–1.04)0.66 (0.49–0.87)0.66 (0.50–0.88)0.81 (0.58–1.12)
  Trachea, bronchus, lung0.99 (0.85–1.14)1.10 (0.94–1.28)1.04 (0.89–1.20)1.05 (0.90–1.21)1.16 (0.98–1.36)
 Bone, connective tissue, skin, breast0.97 (0.58–1.63)0.89 (0.51–1.55)0.99 (0.58–1.67)1.13 (0.66–1.95)1.03 (0.56–1.87)
 Genitourinary organs
  Prostate0.93 (0.70–1.23)0.98 (0.72–1.33)0.94 (0.71–1.25)0.92 (0.69–1.24)0.99 (0.72–1.37)
  Bladder0.84 (0.56–1.25)0.83 (0.54–1.28)0.88 (0.58–1.32)0.86 (0.57–1.28)0.83 (0.53–1.30)
  Kidney1.47 (0.94–2.32)1.26 (0.77–2.06)1.54 (0.97–2.44)1.49 (0.95–2.33)1.21 (0.72–2.03)
 Other and unspecified sites
  Eye, brain, nervous system0.97 (0.64–1.48)0.95 (0.61–1.50)0.99 (0.64–1.50)0.97 (0.64–1.48)0.95 (0.60–1.50)
  Lymphatic, hematopoietic tissues0.94 (0.72–1.24)0.93 (0.69–1.25)0.96 (0.73–1.26)0.95 (0.72–1.25)0.96 (0.71–1.30)
2-h insulin values
 All neoplasms0.91 (0.85–0.98)0.94 (0.87–1.01)0.96 (0.89–1.03)0.93 (0.87–1.00)0.85 (0.78–0.93)
  Lip, oral cavity, pharynx0.75 (0.55–1.02)0.88 (0.63–1.23)0.80 (0.59–1.09)0.81 (0.60–1.09)0.75 (0.52–1.08)
 Digestive organs, peritoneuim
  Esophagus0.89 (0.65–1.23)1.10 (0.78–1.56)0.95 (0.69–1.31)0.90 (0.66–1.23)0.87 (0.60–1.25)
  Stomach0.62 (0.43–0.90)0.63 (0.43–0.92)0.63 (0.44–0.91)0.60* (0.41–0.88)0.68* (0.42–1.08)
  Colon, rectum, anus1.02 (0.80–1.31)0.92 (0.72–1.18)1.02 (0.79–1.30)1.01* (0.78–1.30)0.90* (0.66–1.24)
  Liver3.41 (2.23–5.21)3.05 (1.95–4.77)3.39 (2.22–5.18)3.24 (2.07–5.06)2.18 (1.25–3.79)
  Pancreas0.85 (0.61–1.19)0.84 (0.60–1.19)0.89 (0.63–1.24)0.87 (0.62–1.23)0.73 (0.48–1.10)
 Respiratory, intrathoracic organs
  Larynx0.66 (0.50–0.89)0.77 (0.56–1.05)0.72 (0.54–0.97)0.71 (0.53–0.93)0.62 (0.44–0.88)
  Trachea, bronchus, lung0.90 (0.78–1.04)0.96 (0.82–1.11)0.97 (0.84–1.11)0.93 (0.81–1.08)0.89 (0.74–1.07)
 Bone, connective tissue, skin, breast1.32 (0.77–2.27)1.27 (0.72–2.24)1.36 (0.80–2.33)1.43 (0.81–2.52)1.33 (0.66–2.69)
 Genitourinary organs
  Prostate0.89 (0.66–1.18)0.92 (0.68–1.24)0.90 (0.67–1.21)0.87 (0.65–1.17)0.92 (0.63–1.35)
  Bladder0.87 (0.57–1.31)0.87 (0.57–1.33)0.93 (0.61–1.40)0.90 (0.60–1.34)0.79 (0.48–1.30)
  Kidney1.20 (0.76–1.89)1.05 (0.66–1.66)1.25 (0.79–1.97)1.21 (0.77–1.90)0.78 (0.45–1.35)
 Other and unspecified sites
  Eye, brain, nervous system0.90 (0.59–1.37)0.88 (0.57–1.36)0.91 (0.60–1.39)0.90 (0.59–1.37)0.67 (0.40–1.10)
  Lymphatic, hematopoietic tissues0.98 (0.74–1.30)0.98 (0.73–1.31)1.00 (0.76–1.33)0.03 (0.77–1.36)0.95 (0.67–1.35)
  • Data are ratios (95% CI).

  • *

    * Not adjusted for chronic alcoholism because of low frequency.