Table 1 —

Clinical characteristics of subjects

VariableControl subjects (n = 52)Offspring of diabetic patients
NGT (n = 52)IGT (n = 21)Diabetes (n = 9)
Age (years)41.8 ± 0.941.7 ± 0.945.1 ± 1.350.6 ± 1.9*
Sex (male/female)17/3518/3411/104/5
mtDNA1,304.0 ± 99.21,053.7 ± 74.81,103.3 ± 149.21,220.5 ± 150.1
BMI (kg/m2)24.0 ± 0.323.7 ± 0.424.2 ± 0.725.8 ± 0.7*
Waist-to-hip ratio0.82 ± 0.00.82 ± 0.00.84 ± 0.00.87 ± 0.0*
Fasting glucose (mmol/l)4.8 ± 0.15.0 ± 0.15.3 ± 0.27.7 ± 0.8*
Fasting insulin (pmol/l)60.0 ± 5.246.9 ± 2.860.0 ± 9.787.3 ± 16.8*
Fasting C-peptide (ng/ml)1.4 ± 0.10.6 ± 0.10.6 ± 0.10.8 ± 0.0
Systolic blood pressure (mmHg)117.2 ± 1.9116.9 ± 1.8121.0 ± 2.8121.1 ± 3.5
Diastolic blood pressure (mmHg)76.5 ± 1.375.7 ± 1.380.0 ± 2.376.7 ± 3.7
Cholesterol (mmol/l)4.8 ± 0.14.9 ± 0.15.5 ± 0.25.8 ± 0.4*
Triglyceride (mmol/l)1.4 ± 0.11.6 ± 0.22.4 ± 0.51.8 ± 0.2
HDL (mmol/l)1.2 ± 0.01.2 ± 0.01.2 ± 0.11.2 ± 0.1
Fatty acid (g/l)0.3 ± 0.00.3 ± 0.00.4 ± 0.10.3 ± 0.1
  • Values are means ± SEM; mtDNA represents mtDNA copy number/28S rRNA copy number.

  • *

    * P < 0.05 versus control, NGT, and IGT;

  • P < 0.05 versus control and NGT;

  • P < 0.05 versus control.