Table 1

Characteristics by treatment group

PlaceboMetforminLifestyle
n
 Baseline1,0821,0731,079
 Year 0.51,0191,0241,044
 Year 11,0211,0131,019
 EOS858860899
Weight (kg)
 Baseline94.3 (93.1, 95.5)94.3 (93.1, 95.5)94.1 (92.8, 95.3)
 Year 0.593.7 (93.4, 94.0)91.8 (91.5, 92.1)*87.4 (87.1, 87.7),
 Year 193.6 (93.3, 94.0)91.4 (91.0, 91.7)*87.3 (87.0, 87.7),
 EOS94.3 (93.9, 94.8)92.6 (92.1, 93.0)*90.3 (89.9, 90.8),
Fasting glucose (mmol/L)
 Baseline5.92 (5.90, 5.95)5.91 (5.88, 5.94)5.90 (5.87, 5.93)
 Year 0.55.92 (5.89, 5.95)5.69 (5.66, 5.72)*5.65 (5.62, 5.68)
 Year 15.95 (5.91, 5.98)5.68 (5.64, 5.72)*5.64 (5.60, 5.68)
 EOS6.23 (6.17, 6.29)5.94 (5.88, 6.00)*5.97 (5.91, 6.03)
Fasting insulin (pmol/L)
 Baseline161 (156, 167)163 (158, 168)158 (153, 163)
 Year 1164 (160, 169)138 (135, 142)*124 (121, 128),
 EOS164 (159, 170)147 (142, 152)*140 (135, 144)
CRP (mg/L)
 Baseline3.52 (3.30, 3.75)3.34 (3.13, 3.57)3.53 (3.31, 3.76)
 Year 0.53.50 (3.35, 3.66)3.09 (2.96, 3.23) *2.78 (2.66, 2.90),
 Year 13.40 (3.25, 3.55)2.99 (2.86, 3.12)*2.36 (2.26, 2.46),
 EOS3.44 (3.27, 3.62)2.98 (2.83, 3.14)*2.82 (2.68, 2.96)
tPA (ng/mL)
 Baseline11.40 (11.16, 11.64)11.25 (10.99, 11.50)11.34 (11.09, 11.60)
 Year 110.60 (10.43, 10.78)9.23 (9.06, 9.41)*8.82 (8.64, 8.99),
 EOS11.75 (11.51, 11.99)10.70 (10.46, 10.94)*10.71 (10.47, 10.94)
Fibrinogen (μmol/L)
 Baseline386 (381, 391)380 (375, 385)385 (380, 390)
 Year 1387 (384, 391)383 (379, 387)374 (370, 378),
 EOS376 (371, 381)372 (368, 377)372 (367, 377)
  • Data are expressed as mean and 95% CI except for fasting insulin and CRP, which are expressed as the geometric mean.

  • *P < 0.05 for placebo vs. metformin.

  • P < 0.05 for placebo vs. lifestyle.

  • P < 0.05 for metformin vs. lifestyle.