Table 2

Characteristics by diabetes or nondiabetes status and by intervention group

PlaceboMetforminLifestyle
DiabetesNondiabetesDiabetesNondiabetesDiabetesNondiabetes
n
 Year 0.538987101,01891,037
 Year 11238988093437985
 EOS293595216644141786
Weight (kg)
 Year 0.595.8 (94.8, 96.9)93.8 (93.6, 94.1)93.2 (91.3, 95.1)91.8 (91.6, 92.0)93.7 (91.4, 96.1)87.2 (86.8, 87.5)
 Year 194.3 (93.6, 94.9)93.7 (93.4, 94.0)92.3 (91.5, 93.0)91.3 (91.0, 91.6)89.0 (87.8, 90.2)87.1 (86.7, 87.5)
 EOS95.0 (94.3, 95.7)94.3 (93.8, 94.8)92.7 (91.9, 93.5)92.5 (92.1, 93.0)91.4 (90.4, 92.4)89.9 (89.4, 90.5)
0’ Glucose (mmol/L)
 Year 0.57.01 (6.85, 7.17)5.89 (5.85, 5.92)6.92 (6.63, 7.21)5.68 (5.65, 5.71)7.13 (6.84, 7.42)5.63 (5.60, 5.66)
 Year 16.58 (6.46, 6.70)5.86 (5.82, 5.91)6.23 (6.12, 6.34)5.64 (5.60, 5.67)6.17 (6.01, 6.33)5.60 (5.57, 5.64)
 EOS6.80 (6.68, 6.91)5.98 (5.90, 6.06)6.31 (6.22, 6.41)5.82 (5.76, 5.87)6.82 (6.70, 6.95)5.81 (5.76, 5.86)
0’ Insulin (pmol/L)
 Year 1197 (182, 212)160 (156, 165)160 (146, 176)138 (134, 142)178 (153, 207)121 (118, 125)
 EOS181 (172, 191)157 (151, 163)163 (153, 173)144 (139, 149)185 (171, 199)131 (127, 136)
CRP (mg/L)
 Year 0.54.21 (3.51, 5.06)3.56 (3.42, 3.71)4.86 (3.30, 7.16)2.99 (2.86, 3.13)2.86 (1.83, 4.47)2.79 (2.66, 2.92)
 Year 13.67 (3.30, 4.08)3.45 (3.31, 3.61)3.26 (2.85, 3.72)2.88 (2.75, 3.01)2.85 (2.31, 3.51)2.35 (2.24, 2.46)
 EOS3.69 (3.42, 3.99)3.45 (3.26, 3.65)3.03 (2.76, 3.34)2.86 (2.70, 3.03)3.11 (2.74, 3.53)2.78 (2.63, 2.95)
tPA (ng/dL)
 Year 110.9 (10.4, 11.4)10.6 (10.4, 10.8)9.7 (9.2, 10.3)9.1 (9.0, 9.3)10.2 (9.3, 11.0)8.8 (8.6, 8.9)
 EOS12.4 (12.0, 12.8)11.5 (11.2, 11.8)11.2 (10.7, 11.7)10.5 (10.2, 10.8)11.5 (11.0, 12.1)10.6 (10.3, 10.8)
Fibrinogen (μmol/L)
 Year 1397 (386, 408)389 (385, 393)387 (374, 400)379 (375, 383)386 (366, 406)374 (371, 378)
 EOS385 (377, 394)375 (369, 380)377 (367, 386)367 (362, 372)377 (365, 390)371 (366, 376)
  • Data are expressed as mean (95% CI) except for fasting insulin and CRP, which are expressed as geometric mean with adjustment for baseline levels. Data in bold indicate significant difference between the diabetes versus nondiabetes levels within the treatment group (P < 0.05).