Table 1—

Study subject characteristics

n2,011
Women54.7
Age (years)54 (28–82)
Fasting plasma homocysteine (μmol/l)9.5 (1.4)
Homocysteine >14 μmol/l10.2
Folate (ng/ml)5.6 (2.0)
Vitamin B12 (pmol/l)396.8 (1.7)
PLP (nmol/l)61.0 (1.8)
Plasma creatinine (mg/dl)1.0 (1.2)
UACR*5.7 (4.5)
 <3090.4
 30–3008.9
 >3000.7
Hyperinsulinemia trait12.3
IRS phenotype
 None56.3
 Hypertension12.5
 IGT4.9
 CMS10.3
 Hypertension and CMS6.0
 Impaired glucose tolerance and CMS3.3
 Hypertension, IGT, and CMS6.6
  • Data are inverse transformations of log (mean), log (SD), or %.

  • *

    * A total of 1,592 subjects contributed UACR data;

  • >90th percentile fasting insulin in normal glucose tolerance. CMS, central metabolic syndrome.