Table 2—

Fasting insulin and urine albumin/creatinine levels by IRS phenotype

IRS phenotypes
NoneHTN onlyIGT onlyCMS onlyCMS and HTNCMS and IGTCMS, HTN, and IGT
n1,1332529920812067132
Mean fasting serum insulin (pmol/l)26 (6.1) 635 (6.3)* 631 (6.5) 664 (6.3)* 683 (6.4)* 685 (6.6)* 667 (6.4)*
Hyperinsulinemia2.23.62.230.2*50.1*56.6*37.0*
Number with UACR900195731679553109
Mean UACR (mg/g)5.3 (1.1)7.0 (1.1)6.1 (1.2)4.5 (1.1)6.2 (1.1)7.0 (1.2)8.5 (1.2)
UACR >30 mg/g7.611.38.48.013.816.116.9§
  • Data are inverse tranformations of log (mean), log (SD), or % adjusted for age and sex. HTN, hypertension; CMS, central metabolic syndrome (any two or all of obesity, dyslipidemia, or hyperinsulinemia). Hyperinsulinemia = fasting insulin >90th percentile in normal glucose tolerance. Pairwise statistical comparisons with subjects with no IRS phenoptypes as the reference group are shown for insulin and UACR; other pairwise comparisons are shown for UACR only

  • *

    * P < 0.0001;

  • P ≤ 0.05 compared with no IRS phenotypes;

  • P ≤ 0.05 compared with CMS only;

  • §

    § P < 0.001.