Table 3—

Plasma homocysteine levels by IRS phenotype

IRS phenotypes
NoneHTN onlyIGT onlyCMS onlyCMS and HTNCMS and IGTCMS, HTN, and IGT
n1,1332529920812067132
Mean homocysteine levels
 Age- and sex-adjusted9.310.29.49.49.89.99.7
 Age-, sex-, creatinine-, and vitamin-adjusted9.39.99.49.410.09.99.8
 Sex-, vitamin-, and Cockcroft-Gault equation–adjusted9.110.1§9.69.510.3§10.2*10.2§
Percentage with homocysteine >14 μmol/l
 Age- and sex-adjusted8.814.27.98.313.817.6*11.1
 Age-, sex-, creatinine-, and vitamin-adjusted8.912.6*8.18.214*17.913.2
 Sex-, vitamin-, and Cockcroft-Gault equation–adjusted8.013.48.59.317.020.216.6
  • Data are inverse tranformations of log (mean), log (SD), or % adjusted as indicated (vitamins = folate, B12, and PLP levels). HTN, hypertension; CMS, central metabolic syndrome (any two or all of obesity, dyslipidemia, or hyperinsulinemia). Pairwise statistical comparisons are shown.

  • *

    * P ≤ 0.05 compared with no IRS phenotypes;

  • P < 0.01;

  • P < 0.001;

  • §

    § P < 0.0001;

  • P ≤ 0.05 compared with CMS only;

  • P ≤ 0.05 compared with IGT only.