Table 2—

24-h mean values and changes from baseline for glucose, insulin, and glucagons

Placebo groupGLP-1 4 ng · kg–1 · min–1 16-h groupGLP-1 8 ng · kg–1 · min–1 16-h groupGLP-1 4 ng · kg–1 · min–1 24-h groupGLP-1 8 ng · kg–1 · min–1 24-h group
Glucose (mmol/l)
 Baseline15.315.214.817.218.3
 Change (day 1)−0.2−3.2*−4.4*−4.7*−6.6*
 Change (day 4)+1.1−3.4*−3.7*−4.6*−10.9*
 Change (day 7)+1.3−3.9*−4.7*−5.2*−7.7*
Insulin (μU/ml)
 Baseline3754493630
 Change−3+3−5−7−7
Glucagon (pg/ml)
 Baseline84107118115114
 Change+6−7−30−24−30
  • Compared with placebo,

  • *

    * P < 0.001; compared with other active treatments,

  • P < 0.05; compared with placebo,

  • P < 0.05.