Table 1—

Pathogenesis of LADA

Factors involved in partial and/or slow  progression of β-cell destruction
 Genetic predisposition to type 1 diabetes less marked
 Possible contribution of protective genes toward β-cell destruction
 Partial regeneration of β-cells
 Induction of immune tolerance once the immune process toward β-cells has initiated
 Quantitative/qualitative reduction in the exposure to environmental factors damaging the β-cells