Table 2—

Clinical parameters before and after 4 months of respective treatment

Insulin alone
Insulin plus metformin
Insulin plus troglitazone
BeforeAfterBeforeAfterBeforeAfter
N313127273030
Weight (kg)107.0 ± 26.7111.4 ± 28.0§105.8 ± 22.4106.3 ± 21.5101.1 ± 17.8*105.5 ± 17.4§
Waist-to-hip ratio0.91 ± 0.100.90 ± 0.100.96 ± 0.080.95 ± 0.070.93 ± 0.080.92 ± 0.09
Daily insulin dose (units)80.3 ± 41.7134.9 ± 82.8§82.9 ± 48.281.5 ± 50.196.5 ± 52.783.7 ± 39.1
FPG (mg/dl)192.7 ± 66.6155.9 ± 57.7192.5 ± 54.8150.9 ± 49.2185.6 ± 60.6127.7 ± 41.1#
HbA1c (%)8.7 ± 1.67.0 ± 1.0§8.8 ± 1.27.1 ± 1.0§8.5 ± 1.26.4 ± 0.8§**
Total cholesterol (mg/dl)190.8 ± 42.3189.0 ± 40.3192.9 ± 44.6194.5 ± 43.4196.6 ± 45.5198.8 ± 44.7
HDL cholesterol (mg/dl)38.3 ± 13.639.5 ± 10.631.5 ± 7.131.8 ± 6.734.6 ± 14.436.1 ± 9.6
LDL cholesterol (mg/dl)108.4 ± 29.1111.4 ± 30.6110.7 ± 41.3113.8 ± 35.0112.4 ± 33.0121.7 ± 32.7
Triglyceride (mg/dl)178.3 ± 156.9156.2 ± 114.3226.8 ± 161.3233.6 ± 182.4215.3 ± 146.7169.0 ± 70.2††
VLDL triglyceride (mg/dl)128.1 ± 148.6115.4 ± 108.5161.8 ± 135.4169.3 ± 138.1161.6 ± 133.4109.5 ± 65.9††
  • Data are means ± SD.

  • *

    * P < 0.001 vs. insulin, insulin plus metformin at baseline;

  • P < 0.01 vs. insulin, insulin plus metformin at baseline;

  • P < 0.05 vs. insulin plus metformin, insulin plus troglitazone at baseline;

  • §

    § P < 0.0001 vs. baseline;

  • P < 0.001 vs. insulin plus metformin and insulin plus troglitazone at week 16;

  • P < 0.05 vs. baseline;

  • #

    # P < 0.001 vs. baseline;

  • **

    ** P < 0.05 vs. insulin and insulin plus metformin at week 16;

  • ††

    †† P < 0.05 vs. insulin plus metformin at week 16. FPG, fasting plasma glucose.