Table 3—

Effect of the Trp64Arg mutation of β3-adrenergic receptor gene

ParameterGenotype
Arg/Arg
Trp/Arg
Trp/Trp
ValuePValuePValue
Sex (F/M)26/18293/193616/539
Age (years)57.7 ± 11.30.84658.5 ± 11.80.91158.8 ± 12.7
Height (cm)154.7 ± 8.70.876154.4 ± 8.60.121155.4 ± 9.0
Body weight (kg)60.1 ± 11.00.17256.5 ± 9.90.43057.2 ± 10.0
Fasting plasma glucose (mmol/l)97.6 ± 18.00.43594.9 ± 15.00.99994.9 ± 13.1
2-h plasma glucose (mmol/l)122.0 ± 52.40.522114.2 ± 47.90.997114.0 ± 44.4
Fasting serum insulin (μU/ml)5.84 ± 3.760.036*4.48 ± 3.490.9904.50 ± 3.30
HbA1c (%)5.57 ± 0.720.3715.45 ± 0.530.9995.45 ± 0.53
Waist circumference (cm)82.4 ± 8.820.05878.5 ± 8.940.46479.1 ± 9.03
Hip circumference (cm)94.3 ± 6.400.07291.9 ± 6.200.64592.2 ± 5.92
Waist-to-hip ratio0.873 ± 0.0670.3340.853 ± 0.0690.6560.857 ± 0.070
BMI (kg/m2)25.07 ± 3.840.018*23.66 ± 3.440.98823.63 ± 3.18
Percent body fat28.82 ± 7.950.038*26.46 ± 7.320.45425.96 ± 7.21
Systolic blood pressure (mmHg)128.5 ± 17.90.848125.4 ± 17.20.228127.0 ± 17.3
Diastolic blood pressure (mmHg)74.0 ± 10.60.90473.8 ± 9.440.27574.6 ± 9.84
Total cholesterol (mg/dl)207.3 ± 35.50.916204.5 ± 35.90.951205.1 ± 35.0
Triglycerides (mg/dl)149.0 ± 104.00.114111.6 ± 78.00.441118.3 ± 102.1
HDL cholesterol (mg/dl)53.1 ± 16.00.13658.3 ± 15.30.65057.6 ± 14.3
  • Data are n or means ± SD. P values compared subjects carrying Arg/Arg or Trp/Arg genotype with subjects carrying Trp/Trp genotype.

  • *

    * P < 0.05.