Table 1—

Glucose and insulin metabolism measured using euglycemic-hyperinsulinemic clamps, OGTTs, and fasting glucose and insulin levels in women pregravid and during both early and late pregnancy

PregravidEarly pregnancyLate pregnancy
ISCLAMP (10−2 mg kg−1 · FFM min−1 · uU/ml)
 NGT14.2 ± 1.1*16.4 ± 1.6*9.7 ± 0.7*
 GDM8.8 ± 2.59.8 ± 2.04.9 ± 0.8
Glucose area under the response curve (mg/dl · min)
 NGT4,022 ± 825*5,659 ± 695*9,022 ± 537*
 GDM7,371 ± 1,2999,391 ± 98811,826 ± 711
Insulin area under the response curve (mU/ml · min)
 NGT5,854 ± 832*7,833 ± 1,560*14,263 ± 1,714*
 GDM14,573 ± 4,60518,834 ± 3,65529,512 ± 8,684
Fasting glucose (mg/dl)
 NGT91.8 ± 1.3*85.2 ± 1.281.0 ± 1.0*
 GDM98.0 ± 1.887.4 ± 2.988.6 ± 4.5*
Fasting insulin (uU/ml)
 NGT8.6 ± 0.8*7.6 ± 1.511.3 ± 1.3*
 GDM18.9 ± 4.116.8 ± 5.827.5 ± 5.6
  • Data are means ± SEM (n = 10 NGT; n = 5 GDM). Fasting glucose and insulin measurements were obtained before the OGTT.

  • *

    * Significantly different from the GDM group, (P < 0.05);

  • significantly different from the pregravid levels (P < 0.05).