Table 3—

Patient/control subject differences in SDS for growth measures taken in periods before diagnosis (patients) or qualifying date (control subjects) pooled over five centers

Period before diagnosisn (cases, control subjects)*Height SDS
Weight SDS
BMI SDS
Difference (95% CI)PDifference (95% CI)PDifference (95% CI)P
1 month to 1 year141, 3800.12 (−0.10 to 0.34)0.280.25 (0.05–0.44)0.010.16 (−0.07 to 0.38)0.17
1–2 years170, 4160.17 (−0.01 to 0.36)0.070.37 (0.19–0.55)<0.0010.30 (0.07–0.53)0.01
2–3 years152, 4200.23 (0.02–0.44)0.030.32 (0.14–0.50)<0.0010.22 (0.02–0.42)0.03
3–4 years144, 3760.30 (0.09–0.51)0.0040.37 (0.18–0.55)<0.0010.34 (0.12–0.55)0.002
4–5 years151, 3580.38 (0.13–0.63)0.0030.27 (0.07–0.46)0.0070.19 (−0.03 to 0.40)0.09
5–6 years126, 2920.37 (0.14–0.59)0.0010.28 (0.07–0.49)0.010.06 (−0.18 to 0.29)0.64
  • *

    * Refers to subjects with both height and weight measurements.

  • Significant center-to-center heterogeneity (P < 0.05).