Table —

Insulin secretion and insulin sensitivity in various degrees of glucose tolerance

NGTIGTDM-NFGDM-IFGDM-DFGP*
AUC (insulin)744 ± 359927 ± 508916 ± 527769 ± 479579 ± 356§0.0307
HOMA-IR1.62 ± 0.951.96 ± 1.231.97 ± 1.272.52 ± 1.48§2.26 ± 1.360.1101
ISI-M6.91 ± 3.385.43 ± 2.925.75 ± 4.424.82 ± 2.815.25 ± 2.750.5032
ISI-S0.108 ± 0.0170.082 ± 0.0250.064 ± 0.022§0.071 ± 0.022§0.072 ± 0.022§0.1283
ISI-G83.2 ± 21.653.0 ± 12.335.7 ± 8.4§37.1 ± 9.8§37.8 ± 12.10.2856
ISI-K7.04 ± 0.775.51 ± 0.884.06 ± 0.93§3.42 ± 0.92§2.37 ± 1.51§#<0.0001
  • Data are mean ± SD.

  • *

    * P is the significant correlation among the three diabetic groups (DM-NFG, DM-IFG, and DM-DFG) by Spearman’s correlation test.

  • P < 0.01,

  • P < 0.05 vs. NGT;

  • §

    § P < 0.01 vs. IGT;

  • P < 0.01,

  • P < 0.05 vs. DM-NFG;

  • #

    # P < 0.05 vs. DM-IFG. ISI-G, insulin sensitivity index proposed by Gutt et al.; ISI-K, insulin sensitivity index proposed by Kanauchi; ISI-M, insulin sensitivity index proposed by Matsuda et al.; ISI-S, insulin sensitivity index proposed by Stumvoll et al.