Table 3

Incidence rates of LA in metformin-treated patients stratified by CKD stage

SubgroupPatientsLA eventsPerson-yearsIncidence rate per 
1,000 person-years (95% CI)
All patients77,60135337,590.210.37 (7.22–14.42)
Kidney function
 Normal6,038226,266.07.61 (0.92–27.51)
 Mildly reduced38,8368172,354.44.64 (2.00–9.15)
 Moderately reduced31,27823133,841.817.18 (10.89–25.79)
 Severely reduced1,44925,127.939.00 (4.72–140.89)