Table 5—

Selected weight-loss drugs available in the U.S.

DrugMechanism of actionFA Labeling
PhentermineNonadrenergic; appetite suppression and/or stimulation of metabolic rateShort-term usage
SibutramineSerotonin and norepinephrine reuptake inhibition; appetite suppressionSafety and effectiveness beyond 1 year not determined
OrlistatInhibition of pancreatic lipase; partial malabsorption of fatSafety and effectiveness beyond 2 years not determined