Table 1—

Metabolic and body fat parameters

ParametersGlipizide GITS
Metformin
BaselineMono RxCombo RxBaselineMono RxCombo Rx
Glycemic
 HbA1c (%)10.4 ± 1.510.1 ± 1.5*8.2 ± 1.410.0 ± 1.19.9 ± 1.27.0 ± 0.7
 Fructosamine (μmol/l)432 ± 80374 ± 83298 ± 81398 ± 54355 ± 74234 ± 38
 Fasting glucose (mmol/l)16.7 ± 0.412.3 ± 0.59.6 ± 0.416.3 ± 0.412.6 ± 0.58.5 ± 0.3
Meal tolerance
 Glucose AUC (mmol · min · l−1)4,555 ± 6913,418 ± 7232,766 ± 7154,392 ± 6923,252 ± 7272,223 ± 425
 Insulin AUC (pmol · min · 1−1)33,636 ± 20,21445,672 ± 24,81047,676 ± 25,52435,514 ± 20,41245,882 ± 27,39664,098 ± 32,328
Body fat
 Body weight (kg)94 ± 1894 ± 1797 ± 1995 ± 1894 ± 1696 ± 19
 IAF mass (cm2)132 ± 54128 ± 50142 ± 55175 ± 61175 ± 78184 ± 63
 Total abdominal fat mass (cm2)476 ± 195459 ± 190504 ± 193462 ± 108452 ± 92463 ± 113
HGO (mg · kg−1 · min−1)3.12.32.12.92.41.9
  • Data are means ± SD.

  • *

    * P < 0.02,

  • P < 0.0001,

  • P < 0.05 vs. baseline. IAF, intra-abdominal fat.