Table 1—

Metabolic parameters before (upper line) and after (lower line) treatment with caiapo in the single groups

PlaceboLow doseHigh dose
n666
Fasting plasma glucose (mmol/l)8.2 ± 0.28.8 ± 0.48.3 ± 0.6
8.4 ± 0.38.4 ± 1.17.2 ± 0.4*
Fasting plasma insulin (pmol/l)8.7 ± 1.78.3 ± 1.613.4 ± 2.5
8.7 ± 1.29.0 ± 1.813.2 ± 2.5
Total cholesterol (mmol/l)5.69 ± 0.236.05 ± 0.314.97 ± 0.21
5.66 ± 0.315.68 ± 0.344.45 ± 0.18*
LDL cholesterol (mmol/l)3.72 ± 0.234.11 ± 0.283.12 ± 0.16
3.78 ± 0.413.80 ± 0.282.72 ± 0.16*
HDL cholesterol (mmol/l)1.40 ± 0.101.27 ± 0.101.16 ± 0.05
1.42 ± 0.161.16 ± 0.101.11 ± 0.05
Triglycerides (mmol/l)1.26 ± 0.151.45 ± 0.351.52 ± 0.19
1.37 ± 0.301.61 ± 0.301.33 ± 0.13
HbA1c (%)7.0 ± 0.37.3 ± 0.47.1 ± 0.3
7.0 ± 0.27.3 ± 0.46.8 ± 0.3
Blood pressure (mmHg)134 ± 13147 ± 18135 ± 20
130 ± 18133 ± 19128 ± 21
BMI (kg/m2)28.9 ± 0.925.5 ± 0.828.6 ± 1.3
29.2 ± 0.825.8 ± 0.928.1 ± 1.5
  • Data are means ± SEM.

  • *

    * P < 0.05 compared with pretreatment.