Table 2—

Frequencies of HLA-DQA1 and -DQB1 alleles in Ab-negative and Ab-positive type 1 diabetes

DQ AllelesAb-negative type 1 diabetes
Ab-positive type 1 diabetes, group 3 (n = 78)Nondiabetic control subjects (n = 84)P vs. control subjects (and RR)
Fulminant, group 1 (n = 22)Nonfulminant, group 2 (n = 9)Group 1Group 2Group 3
DQA1*01011 (5)0 (0)8 (10)31 (37)0.034 (0.1)0.042* (0.2)0.001 (0.2)
DQA1*01025 (23)4 (44)20 (26)29 (35)
DQA1*01032 (9)2 (22)7 (9)29 (35)0.029* (0.2)NS0.001 (0.2)
DQA1*02010 (0)0 (0)0 (0)0 (0)
DQA1*03012 (9)3 (33)12 (15)12 (14)
DQA1*03028 (36)5 (56)39 (50)16 (19)NSNS5 × 10−4 (4.3)
DQA1*030315 (68)3 (33)37 (47)27 (32)0.049 (4.5)NSNS
DQA1*04011 (5)0 (0)4 (5)8 (10)
DQA1*05010 (0)0 (0)3 (4)10 (12)
DQA1*06010 (0)0 (0)1 (1)0 (0)
DQB1*05011 (5)0 (0)7 (9)13 (15)
DQB1*05021 (5)0 (0)0 (0)8 (10)NSNS0.009* (0.1)
DQB1*05030 (0)0 (0)1 (1)10 (12)NSNS0.013* (0.1)
DQB1*06012 (9)1 (11)6 (8)28 (33)0.037* (0.2)NS9 × 10−4 (0.2)
DQB1*0602/06032 (9)2 (22)2 (3)14 (17)NSNS0.047 (0.1)
DQB1*06043 (14)3 (33)19 (24)15 (18)
DQB1*02010 (0)0 (0)0 (0)0 (0)
DQB1*03010 (0)1 (11)9 (12)15 (18)
DQB1*03022 (9)3 (33)14 (18)12 (14)
DQB1*03038 (36)5 (56)39 (50)16 (19)NSNS6 × 10−4 (4.3)
DQB1*040115 (68)2 (22)34 (44)17 (20)9 × 10−4 (8.4)NS0.026 (3.0)
DQB1*04021 (5)0 (0)2 (3)11 (13)NSNS0.025* (0.2)
  • Data are n (%). See the text for more detailed definition of each group of subjects. Ab, diabetes-related autoantibodies, including ICAs, GAD autoantibodies, IA-2Abs, and insulin autoantibodies.

  • *

    * Uncorrected P value.