Table 3—

Frequencies of HLA-DQA1-DQB1 haplotypes in Ab-negative and Ab-positive type 1 diabetes

DQA1-DQB1 haplotypesAb-negative type 1 diabetes
Ab-positive type 1 diabetes, group 3 (n = 78)Nondiabetic control subjects (n = 84)P value vs. control subjects (and RR)
Fulminant, group 1 (n = 22)Nonfulminant, group 2 (n = 9)Group 1Group 2Group 3
DQA1*0101-DQB1*05011 (5)0 (0)7 (9)13 (15)
DQA1*0101-DQB1*05020 (0)0 (0)0 (0)8 (10)NSNS0.009* (0.1)
DQA1*0102-DQB1*05021 (5)0 (0)0 (0)0 (0)
DQA1*0101-DQB1*05030 (0)0 (0)1 (1)10 (12)NSNS0.013* (0.1)
DQA1*0103-DQB1*06012 (9)1 (11)6 (8)28 (33)0.037* (0.2)NS0.001 (0.2)
DQA1*0102-DQB1*0602/06032 (9)1 (11)1 (1)14 (17)NSNS0.016 (0.1)
DQA1*0103-DQB1*0602/06030 (0)1 (11)1 (1)0 (0)
DQA1*0102-DQB1*06043 (14)3 (33)19 (24)15 (18)
DQA1*0201-DQB1*02010 (0)0 (0)0 (0)0 (0)
DQA1*0501-DQB1*02010 (0)0 (0)0 (0)0 (0)
DQA1*0303-DQB1*03010 (0)1 (11)5 (6)8 (10)
DQA1*0501-DQB1*03010 (0)0 (0)3 (4)10 (12)
DQA1*0601-DQB1*03010 (0)0 (0)1 (1)0 (0)
DQA1*0301-DQB1*03022 (9)3 (33)12 (15)12 (14)
DQA1*0401-DQB1*03020 (0)0 (0)2 (3)0 (0)
DQA1*0302-DQB1*03038 (36)5 (56)39 (50)16 (19)NSNS0.001 (4.3)
DQA1*0303-DQB1*040115 (68)2 (22)34 (44)17 (20)0.001 (8.4)NS0.040 (3.0)
DQA1*0303-DQB1*04020 (0)0 (0)0 (0)3 (4)
DQA1*0401-DQB1*04021 (5)0 (0)2 (3)8 (10)
  • Data are n (%). See the text for more detailed definition of each group of subjects. Ab, diabetes-related autoantibodies, including ICAs, GAD autoantibodies, IA-2Abs, and insulin autoantibodies.

  • *

    * Uncorrected P value.