Table 2—

Effects of repaglinide on early-phase insulin response in terms of initial slopes (means and SD) after intake of meals

Slope of insulin vs. time curve (pmol · 1−1 · min−1)Two doses
Three doses
Baseline4 weeksChange from baselineBaseline4 weeksChange from baseline
Breakfast (0–30 min)5.6 (3.4)7.4 (4.3)1.8 (2.9)*4.9 (3.2)8.9 (7.1)4.0 (4.8)*
Lunch (240–270 min)2.4 (1.2)2.6 (2.2)0.2 (2.0)4.5 (2.9)6.9 (6.3)2.3 (4.3)
Dinner (600–630 min)1.7 (1.9)3.2 (2.1)1.5 (1.5)*1.7 (2.9)5.5 (5.3)3.8 (3.8)*
  • Data are means (SD).

  • *

    * P < 0.05 for change from baseline.