Table 3—

HbA1c and IGF-1 at entry and follow-up

Progression ≤2 levelsProgression ≥3 levelsP
n31 (81)11 (19)
HbA1c at entry (%)9.8 ± 1.310.0 ± 1.00.65
HbA1c at 12 months (%)7.9 ± 1.07.4 ± 1.50.21
HbA1c at 24 months (%)8.0 ± 1.17.7 ± 1.70.60
HbA1c at 36 months (%)8.0 ± 0.97.8 ± 1.40.73
Average HbA1c*7.9 ± 0.87.4 ± 1.20.59
IGF-1 at entry (μg/l)139 ± 49167 ± 590.13
IGF-1 at 12 months (μg/l)108 ± 31133 ± 640.35
IGF-1 at 24 months (μg/l)99 ± 34116 ± 520.26
IGF-1 at 36 months (μg/l)106 ± 29128 ± 470.003
Average IGF-1*117 ± 35124 ± 470.07
Albuminuria at entry (≤20 mikrog min−1)10/31 (32)4/11 (36)0.9
Albuminuria at 24 months11/29 (38)4/10 (40)0.70
Albuminuria at 36 months11/28 (39)2/6 (33)0.36
Insulin doses per kilogram weight (at 24 months)0.49 ± 0.150.44 ± 0.150.36
  • Data are means ± SD or n (%).

  • *

    * Area under the curve during the study period (36 months).