Table 2—

Baseline and posttreatment nerve function test values

ParameterPlaceboFidarestatDifference (95% CI)P
MNCV in median
    n9586
    Baseline (m/s)51.4 ± 0.551.8 ± 0.4
    End of treatment (m/s)51.2 ± 0.551.8 ± 0.4
    Difference (m/s)−0.2 ± 0.4−0.0 ± 0.40.2 (−0.8 to 1.2)0.74
    95% CI(−0.9 to 0.5)(−0.8 to 0.7)
    P*0.550.90
F wave minimum latency in median
    n9688
    Baseline (ms)31.3 ± 0.331.3 ± 0.3
    End of treatment (ms)31.6 ± 0.330.8 ± 0.3
    Difference (ms)0.3 ± 0.2−0.5 ± 0.20.8 (−1.2 to −0.3)<0.001
    95% CI(−0.1 to 0.6)(−0.8 to −0.2)
    P*0.11<0.01
FCV in median
    n9688
    Baseline (m/s)56.7 ± 0.456.7 ± 0.5
    End of treatment (m/s)56.1 ± 0.457.6 ± 0.5
    Difference (m/s)−0.6 ± 0.30.9 ± 0.31.6 (0.8 to 2.4)<0.001
    95% CI(−1.2 to −0.1)(0.3 to 1.5)
    P*<0.05<0.01
MNCV in tibial
    n9581
    Baseline (m/s)40.2 ± 0.540.1 ± 0.4
    End of treatment (m/s)40.3 ± 0.540.8 ± 0.4
    Difference (m/s)0.1 ± 0.40.8 ± 0.30.7 (−0.3 to 1.6)0.15
    95% CI(−0.6 to 0.8)(0.2 to 1.3)
    P*0.81<0.01
F wave minimum latency in tibial
    n9986
    Baseline (ms)54.8 ± 0.556.0 ± 0.6
    End of treatment (ms)54.4 ± 0.655.1 ± 0.6
    Difference (ms)−0.4 ± 0.3−0.9 ± 0.3−0.5 (−1.3 to 0.4)0.31
    95% CI(−1.0 to 0.2)(−1.5 to −0.2)
    P*0.21<0.05
FCV in tibial
    n9986
    Baseline (m/s)47.7 ± 0.447.0 ± 0.5
    End of treatment (m/s)48.1 ± 0.547.6 ± 0.5
    Difference (m/s)0.4 ± 0.30.6 ± 0.30.2 (−0.6 to 1.0)0.63
    95% CI(−0.2 to 1.0)(0.1 to 1.1)
    P*0.19<0.05
SNCV in median (distal)
    n8267
    Baseline (m/s)47.8 ± 0.848.5 ± 0.9
    End of treatment (m/s)47.6 ± 0.948.8 ± 0.8
    Difference (m/s)−0.1 ± 0.50.3 ± 0.50.4 (−1.0 to 1.9)0.55
    95% CI(−1.2 to 0.9)(−0.7 to 1.3)
    P*0.810.54
SNCV in median (forearm)
    n8676
    Baseline (m/s)57.4 ± 0.657.0 ± 0.7
    End of treatment (m/s)57.4 ± 0.657.6 ± 0.6
    Difference (m/s)−0.0 ± 0.50.6 ± 0.50.6 (−0.8 to 2.0)0.37
    95% CI(−1.1 to 1.0)(−0.3 to 1.5)
    P*0.930.21
  • Data are means ± SEM unless otherwise indicated.

  • *

    * P is the result of one-sample paired t-test within-group comparisons between baseline and posttreatment values, and

  • P is the result of two-sample t-test comparison between groups.