Table 2—

Risk indicators and sequelae of no SH, SH (all episodes), uncomplicated SH, and hypoglycemic Coma during the first trimester of pregnancy in 278 women with type 1 diabetes.

AllNo SHUncomplicated SHHypoglycemic comaSH (all episodes)
n2781656152113
Demographics
 Age (years)30 ±430 ±430 ±429 ±430 ±4
 BMI (kg/m2)24.9 ±3.824.8 ±3.524.7 ±3.725.5 ±4.525.1 ±4.1
 Nullipara5352506055
Diabetes and Treatment
 Diabetes duration (years)12 ±811 ±815 ±7*15 ±615 ±7
 Complicated diabetes26213039*34*
 CSH40424825*37
 Insulin lispro1215787
 Insulin dose/24 h (units/kg)0.74 ±0.290.69 ±0.270.73 ±0.310.88 ±0.300.80 ±0.31
 SMBG >4 times per day7370787978
 HbA1c first trimester (%)6.7 ±0.76.8 ±0.76.5 ±0.8*6.6 ±0.6*6.5 ±0.7
 HbA1c distribution (%)
  ≤6.5463959*5156*
  >6.55461414944
History of SH/Awareness
 History of SH (%)§2511405145
 Reduced awareness (at inclusion) (12)167224030
Sequelae of SH (end of 1st trimester)
 Hypoglycemia Worry level12 ±99 ±714 ±819 ±1016 ±9
 Decreased threshold for symptoms (<3.0 mmol/l)453755*59*57
  • Data are means ±SD or %. P values as compared with no SH.

  • *

    * P<0.05;

  • P<0.005;

  • P<0.001;

  • §

    § ≥1 SH episode (with or without coma) prior to gestation;

  • Hypoglycemic Fear Survey, Worry Scale (points).