Table 2—

Hypoglycemic episodes

IAsp (n=59)
BR (n=59)
Lispro (n=28)
EpisodesRate*EpisodesRate*EpisodesRate*
All reported hypoglycemic episodes
 Entire trial1,5802,2401,159
 Dose-adjustment period4547.7 ±6.457710.3 ±8.128710.3 ±8.2
 Maintenance period1,1266.7 ±5.41,66310.5 ±8.987210.5 ±8.1
(P=0.034)(P=0.044)
Hypoglycemic episodes with BG <50 mg/dl
 Entire trial8411,049482
 Dose-adjustment period2313.9 ±4.22794.9 ±4.61234.4 ±5.6
 Maintenance period6103.7 ±3.67704.8 ±4.23594.4 ±4.7
(P=0.175)(P=0.841)
Nocturnal hypoglycemic episodes with BG <50 mg/dl§
 Entire trial12226579
 Dose-adjustment period260.4 ±0.95581.0 ±1.36150.5 ±0.74
 Maintenance period960.5 ±0.832070.9 ±0.97640.6 ±0.61
(P=0.004)(P=0.189)
  • Data are n or means ±SD.

  • *

    * Rate equals the mean number (± SD) of hypoglycemic episodes reported per subject per 30 days for all subjects in the treatment group;

  • all reported hypoglycemic episodes regardless of BG value;

  • Wilcoxon rank-sum test, relative to the rate in the IAsp group during the maintenance period;

  • §

    § hypoglycemic episode with BG <50 mg/dl, occurring between midnight and 6:00 a.m.