Table 2—

Biochemical and RAS parameters in losartan and placebo groups

Losartan
Placebo
Week 0Week 2Week 4ANOVAWeek 0Week 2Week 4ANOVA
Urinary sodium excretion
 Regular-sodium diet255 ± 33222 ± 23208 ± 20NS208 ± 15207 ± 27204 ± 27NS
 Low-sodium diet225 ± 24226 ± 2585 ± 14§<0.0001205 ± 29163 ± 1780 ± 22§0.0007
Fasting plasma glucose (mmol/l)
 Regular-sodium diet10.5 ± 1.39.8 ± 1.29.3 ± 1.2NS9.8 ± 1.410.7 ± 1.29.6 ± 1.4NS
 Low-sodium diet9.1 ± 0.78.9 ± 0.77.7 ± 0.6*0.0469.8 ± 0.79.1 ± 0.78.5 ± 1.5NS
PRA (ng · ml−1 · h−1)
 Regular-sodium diet0.47 (1.28)1.31 (1.63)1.09 (1.52)0.00040.49 (1.31)0.51 (1.27)0.43 (1.27)NS
 Low-sodium diet0.57 (1.29)0.99 (1.46)3.07 (1.63)§<0.00010.57 (1.31)0.57 (1.3)0.92 (1.3)<0.01
Plasma ANG-II (pg/ml)
 Regular-sodium diet4.51 (1.24)8.25 (1.41)10.04 (1.41)0.0016.84 (1.29)5.82 (1.25)6.49 (1.21)NS
 Low-sodium diet5.65 (1.29)9.16 (1.4)24.71 (1.53)§0.00026.06 (1.19)6.65 (1.37)10.8 (1.16)*0.02
Plasma aldosterone (pmol/l)
 Regular-sodium diet188.1 ± 33.3273 ± 76.7190.8 ± 38.7NS200.7 ± 43.2233.4 ± 52.5208.4 ± 31.4NS
 Low-sodium diet209 ± 32.3166.9 ± 34.5345.3 ± 51.5§0.0009173.9 ± 36.8192 ± 34.5401 ± 53.4§<0.0001
  • Data for PRA and ANG-II are geometric means (tolerance factor); data for urinary sodium excretion, fasting plasma glucose, and aldosterone are expressed as means ± SEM.

  • *

    * P < 0.05 vs. week 0;

  • P < 0.01 vs. week 0;

  • P < 0.05 vs. week 2;

  • §

    § P < 0.01 vs. week 2.