Table 4—

Hemodynamic and renal parameters during losartanRS and losartanLS

ParameterLosartanRS
LosartanLS
Δ LosartanLS − Δ losartanRS
P
Week 2Week 4Δ Week 4–2Week 2Week 4ΔWeek 4–2Δ
Blood pressure (mmHg)
 24-h
  Systolic139.6 ± 3.9139.6 ± 4.80 ± 2.1141.4 ± 4.0131.7 ± 3.5−9.7 ± 2.7−9.7 (−17.2 to −2.2)0.002
  Diastolic77.8 ± 1.578.2 ± 1.80.4 ± 0.978.9 ± 1.273.8 ± 1.8−5.1 ± 1.4−5.5 (−8.4 to −2.6)0.002
  Mean arterial pressure99.3 ± 1.998.9 ± 2.4−0.4 ± 1.5100.6 ± 1.892.9 ± 1.9−7.7 ± 1.7−7.3 (−11.3 to −3.3)0.003
 Awake
  Systolic142.5 ± 4142.1 ± 4.9−0.4 ± 2.2143.5 ± 4.5133.6 ± 4.0−9.9 ± 3.2−9.5 (−18.4 to −0.6)0.039
  Diastolic80.2 ± 1.680.1 ± 1.8−0.1 ± 0.880.7 ± 1.475.3 ± 2.0−5.4 ± 1.8−5.3 (−9.3 to −1.3)0.015
  Mean arterial pressure101.8 ± 2.1100.5 ± 2.3−1.3 ± 1.4101.1 ± 2.794.1 ± 2.4−7.0 ± 2.6−5.7 (−11.3 to −0.1)0.048
 Sleep
  Systolic129.9 ± 3.4129.6 ± 5.3−0.3 ± 2.3134.2 ± 3.7123.8 ± 3.1−10.4 ± 3.2−10.1 (−19.7 to −0.5)0.041
  Diastolic70.3 ± 2.170.3 ± 2.20 ± 1.872.5 ± 1.767.7 ± 2.2−4.8 ± 1.5−4.8 (−11.2 to 1.5)0.12
  Mean arterial pressure91.4 ± 1.891.1 ± 2.9−0.3 ± 1.994.8 ± 1.688.2 ± 1.6−6.6 ± 2.0−6.3 (−12.8 to 0.8)0.065
GFR (ml · min−1 · 1.73m−2)101.1 ± 6.198.8 ± 6.3−2.3 ± 2.196.9 ± 6.791.9 ± 5.9−5.0 ± 1.7−2.7 (−8.1 to 2.6)0.28
MAG-3 ERPF (ml · min−1 · 1.73 m−2)272.9 ± 21.8267.3 ± 23.4−5.6 ± 9.9275.5 ± 20.9269.2 ± 19.6−6.3 ± 9.3−0.7 (−26 to 25)0.95
FF (%)20.1 ± 1.020.2 ± 1.30.2 ± 1.018.8 ± 0.818.2 ± 0.6−0.6 ± 0.4−0.7 (−3.3 to 1.8)0.53
PGC (mmHg)53.3 ± 3.851.9 ± 3.6−1.4 ± 1.754.4 ± 3.945.4 ± 4.4−9.0 ± 1.7−7.6 (−11.8 to −3.5)0.002
  • Data expressed as means ± SEM or mean difference (95% CI).