Table 3—

Changes in diabetes medications after 52 weeks of treatment

PlaceboOrlistatP
n269266
Changes in daily dosages of diabetes medications
 Insulin (units/day)−1.6 ± 1.7−8.1 ± 1.50.007
 Decrease in insulin dose ≥5.0%31.041.20.0085
 Increase in insulin dose ≥5.0%25.711.80.000
 Sulfonylurea (mg/day)1.3 ± 4.1−7.8 ± 6.20.037
 Metformin (mg/day)163 ± 66190+ ± 650.343
Frequency distribution of medication changes over 52 weeks0.000
 No change in any medications37.544.0
 Decreased dose or discontinued at least one medication30.941.3
 Increased dose or added at least one medication31.714.7
  • Data are means ± SE or %.