Table 3—

RRs of stroke according to clinical diabetes status: the NHS 1976–1996

Nondiabetic throughout the studyDiabetic at baseline (1976)New diabetes diagnosed at follow-up
RRs prior to diagnosisRRs after the diagnosis
Nonfatal stroke
n8826159103
 Person-years2,103,93625,35266,93942,061
 Age-adjusted1.04.53 (3.49–5.88)2.53 (1.94–3.31)3.34 (2.72–4.11)
 Multivariate*1.04.41 (3.43–5.67)2.30 (1.76–2.99)3.15 (2.56–3.88)
Fatal stroke
n2592120
 Age-adjusted1.05.43 (3.48–8.51)1.29 (0.85–2.03)
 Multivariate1.05.25 (3.34–8.24)1.38 (0.87–2.20)
Total Stroke
n1,14182123
 Age-adjusted1.04.74 (3.78–5.94)3.17 (2.62–3.83)
 Multivariate1.04.56 (3.63–5.73)3.07 (2.53–3.73)
  • Data are n, RR, and RR (95% CI).

  • *

    * Models include the following: age (5-year category); time period (10 periods); BMI (<21, 21–22.9, 23–24.9, 25–28.9, 29–31.9, and ≥32 kg/m2); cigarette smoking (never, past, and current smoking of 1–14, 15–24, and ≥25 cigarettes/day); menopausal status (premenopausal, postmenopausal without hormone replacement, postmenopausal with past hormone replacement, and postmenopausal with current hormone replacement); and parental history of MI before 60 years of age.