Table 2—

RR of CHD among diabetic women according to BMI*

BMI (kg/m2)
P for trend
<2020.0–22.923.0–24.925.0–26.927.0–29.930.0–34.9≥35.0
Current BMI (updated every 2 years)
N3538477712992
 Age-adjusted1.001.43 (0.90–2.26)1.61 (1.04–2.51)1.70 (1.14–2.55)2.42 (1.66–3.52)2.73 (1.84–4.06)<0.001
 Multivariate1.001.58 (0.99–2.52)1.85 (1.18–2.88)1.95 (1.30–2.95)2.80 (1.90–4.13)3.21 (2.13–4.84)<0.001
 Multivariate (among incident diabetic women: n = 229 cases of CHD)1.002.31 (1.11–4.80)2.17 (1.06–4.45)2.43 (1.24–4.75)2.91 (1.52–5.59)4.17 (2.15–8.12)<0.001
 Multivariate (among prevalent diabetic women: n = 189 cases of CHD)1.001.12 (0.59–2.13)1.70 (0.94–3.07)1.67 (0.97–2.88)3.10 (1.90–5.07)2.44 (1.40–4.27)<0.001
BMI in 1976 (study entry)
N4041428013778
 Age-adjusted1.001.32 (0.85–2.04)1.49 (0.96–2.30)1.82 (1.24–2.66)2.95 (2.07–4.21)3.13 (2.13–4.60)<0.001
 Multivariate1.001.53 (0.98–2.38)1.68 (1.08–2.62)2.02 (1.37–2.99)3.26 (2.26–4.71)3.43 (2.30–5.11)<0.001
 Multivariate (among incident diabetic women: n = 229 cases of CHD)1.002.02 (0.99–4.12)1.89 (0.94–3.80)2.27 (1.19–4.34)3.82 (2.04–7.12)4.44 (2.31–8.53)<0.001
 Multivariate (among prevalent diabetic women: n = 189 cases of CHD)1.001.21 (0.67–2.19)1.60 (0.87–2.94)1.99 (1.19–3.33)3.12 (1.95–4.99)2.77 (1.61–4.77)<0.001
BMI at 18 years of age
N62101695645
 Age-adjusted1.001.19 (0.87–1.64)1.78 (1.26–2.52)1.78 (1.24–2.57)3.90 (2.64–5.78)<0.001
 Multivariate1.001.15 (0.84–1.58)1.63 (1.15–2.32)1.51 (1.04–2.19)3.06 (2.05–4.55)<0.001
 Multivariate (among incident diabetic women: n = 190 cases of CHD)1.001.18 (0.77–1.81)1.62 (1.01–2.58)1.61 (0.99–2.60)2.90 (1.66–5.05)<0.001
 Multivariate (among prevalent diabetic women: n = 144 cases of CHD)1.001.16 (0.71–1.88)1.64 (0.97–2.77)1.45 (0.81–2.59)3.22 (1.80–5.75)<0.001
  • *

    * Data are RR (95% CI). Prevalent diabetic cases are women with existing diabetes in 1976, and incident diabetic cases are women who developed diabetes between 1976 and 1994;

  • P value, test for trend;

  • adjusted for age (5-year categories), smoking (never, past, current 1–14, current 15–24, current 25+ cigarettes per day), use of postmenopausal hormone (premenopausal, never, past, current), parental history of myocardial infarction before 60 years of age (yes or no), duration of diabetes (≤5, 6–10, 11–15, ≥15 years), insulin or other hypoglycemic treatment usage (no, oral medication only, insulin and/or oral medication), and time period (10 periods).