Table 3—

Differences between PCOS and control subjects in DI

InsulinControl
PCOS (BMI <27)
PCOS (BMI ≥27)
Between-group differences
SecretionSensitivitynMedianLower quartileUpper quartilenMedianLower quartileUpper quartilenMedianLower quartileUpper quartilePSignificant between-group differences (P < 0.05)
HOMA-F1/HOMA-R20113.675.95130.83710060153.1246050.9182.590.03CO, LO
HOMA-FI/I02022.2216.0325372013.3328.572413.3311.7616.870.003CO, LO
HOMA-FG0/I02097.7876.09107.5379466.67122.32466.6757.0279.30.002CO, LO
HOMA-F1/FIRI20126.384.39145.337111.166.67170.12466.6756.5691.770.007CO, LO
ΔI/ΔG30-0I/I120200.6490.3570.965361.1040.4752.555240.6790.281.2520.007CL, LO
ΔI/ΔG30-0AUC-G/AUC-I200.1120.0450.169350.1820.0560.558230.0660.0160.1340.0003CO, LO, (CL)
ΔI/ΔG30-0Cederholm20906.3581.81295351634882.42937241554962.825690.0003CL, CO
ΔI/ΔG30-0Matsuda201844908.4229436294213984832241946113727870.05CL, (LO)
ΔI/ΔG30-01/Suma I200.1460.0970.216360.3170.1530.501240.1440.10.290.002CL, LO
HOMA-FKITT207.2765.53310.15511.599.58213.588.8282.46920.85NS*
HOMA-F1/AUCITT202.2761.483.28953.2572.9525.69282.6210.9167.249NS
HOMA-F1/ITTmin2067.5848.7121.9511098.72128.2885.9923.63210.5NS
ΔI/ΔG30-0KITT200.7270.4950.94452.2631.9883.82181.4290.7211.7850.0001CO, LO, CL
ΔI/ΔG30-01/AUCITT200.2430.1560.351.0250.6121.07480.4520.210.6560.0008LO, CL
ΔI/ΔG30-01/ITTmin206.6484.56411.2521.520.4829.72814.576.295160.0008LO, CL
  • *

    * Due to nonconstant variance even after transformation to minimum skewness of normalized residues with absolute values <2, Kruskall-Wallis test followed by Mann-Whitney U test was used instead of ANOVA. CL, control vs. lean PCOS subjects; CO, control vs. obese PCOS subjects; LO, lean vs. obese PCOS subjects.